Striatal dopamine release during performance of executive functions: A [11C] raclopride PET study
Identifieur interne : 002710 ( Main/Exploration ); précédent : 002709; suivant : 002711Striatal dopamine release during performance of executive functions: A [11C] raclopride PET study
Auteurs : Oury Monchi [Canada] ; Ji Hyun Ko [Canada] ; Antonio P. Strafella [Canada]Source :
- NeuroImage [ 1053-8119 ] ; 2006.
Abstract
To date, while the contribution of the striatum in executive processes is well documented, the role played by striatal dopamine during tasks requiring executive functions is still unknown. We used D2-dopamine receptor ligand [11C] raclopride PET in healthy subjects while performing the Montreal Card Sorting Task (MCST). We observed a striatal reduction in [11C] raclopride binding potential during planning of a set-shift when compared with matching according to an ongoing rule. These findings suggest that striatal dopamine neurotransmission increases significantly during the performance of specific executive processes confirming previous evidence of striatal activation during fMRI studies. The present observation may provide some insights on the origin of cognitive deficits underlying certain neurological disorders associated with dopamine dysfunction, such as Parkinson’s disease.
Url:
DOI: 10.1016/j.neuroimage.2006.06.058
PubMed: 16982202
PubMed Central: 2967527
Affiliations:
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McGill University, 3801 University St., Montréal, QC, Canada H3A 2B4</nlm:aff><country>Canada</country><wicri:regionArea> Montreal Neurological Institute, Neurology and Neurosurgery Dept. McGill University, 3801 University St., Montréal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name><affiliation wicri:level="1"><nlm:aff id="A2"> Montreal Neurological Institute, Neurology and Neurosurgery Dept. McGill University, 3801 University St., Montréal, QC, Canada H3A 2B4</nlm:aff><country>Canada</country><wicri:regionArea> Montreal Neurological Institute, Neurology and Neurosurgery Dept. 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McGill University, 3801 University St., Montréal, QC, Canada H3A 2B4</nlm:aff><country>Canada</country><wicri:regionArea> Montreal Neurological Institute, Neurology and Neurosurgery Dept. McGill University, 3801 University St., Montréal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name><affiliation wicri:level="1"><nlm:aff id="A2"> Montreal Neurological Institute, Neurology and Neurosurgery Dept. McGill University, 3801 University St., Montréal, QC, Canada H3A 2B4</nlm:aff><country>Canada</country><wicri:regionArea> Montreal Neurological Institute, Neurology and Neurosurgery Dept. McGill University, 3801 University St., Montréal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author></analytic><series><title level="j">NeuroImage</title><idno type="ISSN">1053-8119</idno><idno type="eISSN">1095-9572</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">To date, while the contribution of the striatum in executive processes is well documented, the role played by striatal dopamine during tasks requiring executive functions is still unknown. We used D2-dopamine receptor ligand [<sup>11</sup>C] raclopride PET in healthy subjects while performing the Montreal Card Sorting Task (MCST). We observed a striatal reduction in [<sup>11</sup>C] raclopride binding potential during planning of a set-shift when compared with matching according to an ongoing rule. These findings suggest that striatal dopamine neurotransmission increases significantly during the performance of specific executive processes confirming previous evidence of striatal activation during fMRI studies. The present observation may provide some insights on the origin of cognitive deficits underlying certain neurological disorders associated with dopamine dysfunction, such as Parkinson’s disease.</p></div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Monchi, Oury" sort="Monchi, Oury" uniqKey="Monchi O" first="Oury" last="Monchi">Oury Monchi</name></noRegion><name sortKey="Ko, Ji Hyun" sort="Ko, Ji Hyun" uniqKey="Ko J" first="Ji Hyun" last="Ko">Ji Hyun Ko</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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